Okay to take 6.0.1 update on unlocked bootloader?

I thought it would be easy to find an answer to this question... but I haven't been able to find my specific situation.

I'm wondering if it is okay to take the 6.0.1 update? Everything is still stock except the only thing I have done is unlock the bootloader. I know you would normally not want to, but I wasn't sure if the bootloader is impacted or affects any system updates.

Thanks ;)

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